2020
Breakage of the oligomeric CaMKII hub by the regulatory segment of the kinase
Deepti Karandur*, Moitrayee Bhattacharyya*, Zijie Xia*, Young Kwang Lee, Serena Muratcioğlu, Darren McAffee, Ethan D McSpadden, Baiyu Qiu, Jay T Groves, Evan R Williams and John Kuriyan
Elife 2020;9:e57784 doi: 10.7554/eLife.57784
BioRχiv 2020.04.15.043067; doi: https://doi.org/10.1101/2020.04.15.043067
CRISPR-Cas12a exploits R-loop asymmetry to form double-strand breaks
Joshua C Cofsky, Deepti Karandur, Carolyn J Huang, Isaac P Witte, John Kuriyan and Jennifer A Doudna
Elife 2020;9:e55143 doi: 10.7554/eLife.55143
Flexible linkers in CaMKII control the balance between activating and inhibitory autophosphorylation
Moitrayee Bhattacharyya, Young Kwang Lee, Serena Muratcioğlu, Baiyu Qiu, Priya Nyayapati, Howard Schulman, Jay T. Groves and John Kuriyan
Elife 2020;9:e53670 doi:10.7554/eLife.53670
2019
Cryo-EM structure of a dimeric B-Raf:14-3-3 complex reveals asymmetry in the active sites of B-Raf kinases
Yasushi Kondo*, Jana Ognjenović*, Saikat Banerjee, Deepti Karandur, Alan Merk, Kayla Kulhanek, Kathryn Wong, Jeroen P. Roose, Sriram Subramaniam and John Kuriyan
Science 2019 366:109–115 Epub Sep 19
doi: 10.1126/science.aay0543
Switch-like activation of Bruton's tyrosine kinase by membrane-mediated dimerization
Jean K. Chung*, Laura M. Nocka*, Aubrianna Decker, Qi Wang, Theresa A. Kadlecek, Arthur Weiss, John Kuriyan and Jay T. Groves
Proc Natl Acad Sci USA 2019 116(22):10798-10803
doi: https://doi.org/10.1101/284000
BioRχiv 284000; doi: https://doi.org/10.1101/284000
Variation in assembly stoichiometry in non-metazoan homologs of the hub domain of Ca2+/Calmodulin-dependent protein kinase II
Ethan D. McSpadden, Zijie Xia, Chris C. Chi, Anna C. Susa, Neel H. Shah, Christine L. Gee, Evan R. Williams and John Kuriyan
Protein Science 2019 28:1071–1082 Epub Apr 3 doi: https://doi.org/10.1002/pro.3614
BioRχiv 536094; doi: https://doi.org/10.1101/536094
2018
Deep mutational analysis reveals functional trade-offs in the sequences of EGFR autophosphorylation sites
Aaron C. Cantor, Neel H. Shah and John Kuriyan
Proc Natl Acad Sci USA 2018 115(31):E7303-E7312 Epub July 16
doi: 10.1073/pnas.18035981152018
BioRχiv 273516; doi: https://doi.org/10.1101/273516
Fine-tuning of substrate preferences of the Src-family kinase Lck revealed through a high-throughput specificity screen
Neel H. Shah, Mark Löbel, Arthur Weiss and John Kuriyan
eLife 2018;7:e35190 doi:10.7554/eLife.35190
BioRχiv 250753; doi: https://doi.org/10.1101/250753
Phosphorylation Control of the Ubiquitin Ligase Cbl is Conserved in Choanoflagellates
Jeanine F. Amacher, Helen T. Hobbs, Aaron C. Cantor, Lochan Shah, Marco-Jose Rivero,
Sarah A. Mulchand and John Kuriyan
Protein Science 2018 27(5):923-932. Epub 2018 Mar 2. doi: 10.1002/pro.3397
2017
A Histidine pH sensor regulates activation of the Ras-specific guanine nucleotide exchange factor RasGRP1
Yvonne Vercoulen*, Yasushi Kondo*, Jeffrey S. Iwig*, Axel B. Janssen, Katharine A. White, Mojtaba Amini, Diane L. Barber, John Kuriyan and Jeroen P. Roose
eLife 2017;6:e29002. doi: 10.7554/eLife.29002
Multiple interactions between an Arf/GEF complex and charged lipids determine activation kinetics on the membrane
Deepti Karandur*, Agata Nawrotek*, John Kuriyan and Jacqueline Cherfils
Proc Natl Acad Sci U S A 2017 Oct 24;114(43):11416-11421. Epub 2017 Sep 18.
doi: 10.1073/pnas.1707970114
Deconstruction of the Ras switching cycle through saturation mutagenesis
Pradeep Bandaru, Neel H. Shah, Moitrayee Bhattacharyya, John P. Barton, Yasushi Kondo, Joshua C. Cofsky, Christine L. Gee, Arup K. Chakraborty, Tanja Kortemme, Rama Ranganathan and John Kuriyan
eLife 2017;6:e27810 doi: 10.7554/eLife.27810
Identification of inhibitors of the association of ZAP-70 with the T cell receptor
by high-throughput screen
Patrick R. Visperas, Christopher G. Wilson, Jonathan A. Winger, Qingrong Yan, Kevin Lin, Michelle R. Arkin, Arthur Weiss and John Kuriyan
SLAS Discov. 2017 Mar 1;22(3):324-331. Epub 2016 Dec 13
doi: 10.1177/1087057116681407
2016
An electrostatic selection mechanism controls sequential kinase signaling downstream of the T cell receptor
Neel H. Shah, Qi Wang, Qingrong Yan, Deepti Karandur, Theresa A. Kadlecek, Ian R. Fallahee, William P. Russ, Rama Ranganathan, Arthur Weiss and John Kuriyan
eLife 2016 Oct 4;5:e20105. doi: 10.7554/eLife.20105
Molecular basis for multimerization in the activation of the epidermal growth factor receptor
Yongjian Huang*, Shashank Bharill*, Deepti Karandur, Sean M. Peterson, Morgan Marita, Xiaojun Shi, Megan J. Kaliszewski, Adam W. Smith, Ehud Y. Isacoff and John Kuriyan
eLife 2016 Mar 28;5:e14107.
doi: 10.7554/eLife.14107.
Molecular mechanism of activation-triggered subunit exchange in Ca2+/calmodulin-dependent protein kinase II
Moitrayee Bhattacharyya*, Margaret M. Stratton*, Catherine C. Going*, Ethan McSpadden, Yongjian Huang, Anna C. Susa, Anna Elleman, Yumeng Melody Cao, Nishant Pappireddi, Pawel Burkhardt, Christine L. Gee, Tiago Barros, Howard Schulman, Evan R. Williams and John Kuriyan
eLife 2016 Mar 7;5:e13405.
doi: 10.7554/eLife.13405.
Crystal Structure of a Ube2S-Ubiquitin Conjugate
Sonya Lorenz, Moitrayee Bhattacharyya, Christian Feiler, Michael Rape and John Kuriyan
PLoS One 2016 Feb 1;11(2):e0147550. doi: 10.1371/journal.pone.0147550
2015
Crystal structure of the FLT3 kinase domain bound to the inhibitor Quizartinib (AC220)
Julie A. Zorn, Qi Wang, Eric Fujimura, Tiago Barros and John Kuriyan
PLoS One 2015 Apr 2;10(4):e0121177. doi: 10.1371/journal.pone.0121177
Analysis of the role of the C-terminal tail in the regulation of the epidermal growth factor receptor
Erika Kovacs*, Rahul Das*, Qi Wang, Timothy S. Collier, Aaron Cantor, Yongjian Huang, Kathryn Wong, Amar Mirza, Tiago Barros, Patricia Grob, Natalia Jura, Ron Bose and John Kuriyan
Mol Cell Biol. 2015 Sep 1;35(17):3083-102.
doi: 10.1128/MCB.00248-15. Epub 2015 Jun 29.
Crystal structure of an SH2-kinase construct of c-Abl and effect of the SH2 domain on kinase activity
Sonja Lorenz, Patricia Deng, Oliver Hantschel, Giulio Superti-Furga and John Kuriyan
Biochem. J. 2015, Jun 1;468(2):283-91 doi: 10.1042/BJ20141492
Autoinhibition of Bruton's tyrosine kinase (Btk) and activation by soluble inositol hexakisphosphate
Qi Wang, Erik M Vogan, Laura M Nocka, Connor E Rosen, Julie A Zorn, Stephen C Harrison and John Kuriyan
eLife 2015 10.7554/eLife.06074 doi: 10.7554/eLife.06074
Modification by covalent reaction or oxidation of cysteine residues in the Tandem-SH2 Domains of ZAP-70 and Syk Can Block Phosphopeptide Binding
Patrick R. Visperas, Jonathan A. Winger, Timothy M. Horton, Neel H. Shah, Diane J. Aum, Alyssa Tao, Tiago Barros, Qingrong Yan, Christopher G. Wilson, Michelle R. Arkin, Arthur Weiss and John Kuriyan
Biochem J. 2015;465(1):149-61 doi: 10.1042/BJ20140793
2014
Activation-triggered subunit exchange between CaMKII holoenzymes facilitates the spread of kinase activity
Margaret Stratton, Il-Hyung Lee, Moitrayee Bhattacharyya, Sune M Christensen, Luke H Chao, Howard Schulman, Jay T Groves and John Kuriyan
eLife 2014 Jan 1;3:e01610. doi: 10.7554/eLife.01610
2013
Structural analysis of autoinhibition in the Ras-specific exchange factor RasGRP1
Jeffrey S. Iwig, Yvonne Vercoulen, Rahul Das, Tiago Barros, Andre Limnander, Yan Che, Jeffrey G. Pelton, David E. Wemmer, Jeroen P. Roose and John Kuriyan
eLife 2013 Jul 30;2:e00813. doi: 10.7554/eLife.00813
A structural role for the PHP domain in E. coli DNA polymerase III
Tiago Barros*, Joel Guenther*, Brian Kelch, Jordan Anaya, Arjun Prabhakar, Mike O'Donnell, John Kuriyan and Meindert H. Lamers
BMC Struct Biol. 2013 May 14;13:8.
doi: 10.1186/1472-6807-13-8
A highly efficient peptide substrate for EGFR activates the kinase by inducing aggregation
Kate Engel, Tomoaki Sasaki, Qi Wang and John Kuriyan
Biochem J. 2013 Aug 1;453(3):337-44. doi: 10.1042/BJ20130537
Structural Basis for Activation of ZAP-70 by Phosphorylation of the SH2-Kinase Linker
Qingrong Yan, Tiago Barros, Patrick R. Visperas, Sebastian Deindl, Theresa A. Kadlecek, Arthur Weiss and John Kuriyan
Mol Cell Biol. 2013 Jun;33(11):2188-201. doi: 10.1128/MCB.01637-12
Conformational Coupling across the Plasma Membrane in Activation of the EGF Receptor
Nicholas F. Endres*, Rahul Das*, Adam W. Smith*, Anton Arkhipov, Erika Kovacs, Yongjian Huang, Jeffrey G. Pelton, Yibing Shan, David E. Shaw, David E. Wemmer, Jay T. Groves and John Kuriyan
Cell 2013 Jan 31;152(3):543-56.
doi: 10.1016/j.cell.2012
2011
How a DNA polymerase clamp loader opens a sliding clamp
Brian A. Kelch*, Debora L. Makino*, Michael O'Donnell and John Kuriyan
Science 2011 Dec 23;334(6063):1675-80.
doi: 10.1126/science.1211884
A mechanism for tunable autoinhibition in the structure of a human Ca2+/calmodulin-dependent kinase II holoenzyme
Luke H. Chao, Margaret M. Stratton, Il-Hyung Lee, Oren S. Rosenberg, Joshua Levitz, Daniel J. Mandell, Tanja Kortemme, Jay T. Groves, Howard Schulman and John Kuriyan
Cell 2011 Sep 2;146(5):732-45. doi: 10.1016/j.cell.2011.07.038
The Mechanism of Linkage-Specific Ubiquitin Chain Elongation by a Single-Subunit E2
Katherine E Wickliffe*, Sonja Lorenz*, David E. Wemmer, John Kuriyan and Michael Rape
Cell 2011 Mar 4;144(5):769-81. doi: 10.1016/j.cell.2011.01.035
2010
Intersubunit capture of regulatory segments is a component of cooperative CaMKII activation
Luke H Chao, Patricia Pellicena, Sebastian Deindl, Lauren A Barclay, Howard Schulman and John Kuriyan
Nat Struct Mol Biol. 2010 Mar;17(3):264-72. doi: 10.1038/nsmb.1751
Role of the histone domain in the autoinhibition and activation of the Ras activator Son of Sevenless
Jodi Gureasko, Olga Kuchment, Debora Lika Makino, Holger Sondermann, Dafna Bar-Sagi and John Kuriyan
Proc Natl Acad Sci U S A.2010 Feb 23;107(8):3430-5. doi: 10.1073/pnas.0913915107
Analysis of the role of PCNA-DNA contacts during clamp loading
Randall McNally, Gregory D Bowman, Eric R Goedken, Mike O'Donnell and John Kuriyan
BMC Struct. Biol.2010 Jan 30;10:3. doi: 10.1186/1472-6807-10-3
2009
Structural analysis of the catalytically inactive kinase domain of the human EGF receptor 3
Natalia Jura, Yibing Shan, Xiaoxian Cao, David Shaw and John Kuriyan
Proc Natl Acad Sci U S A.2009 Dec 22;106(51):21608-13. doi: 10.1073/pnas.0912101106
Stability of an autoinhibitory interface in the structure of the tyrosine kinase ZAP-70 impacts T cell receptor response
Sebastian Deindl, Theresa A. Kadlecek, Xiaoxian Cao, John Kuriyan and Arthur Weiss
Proc Natl Acad Sci U S A. 2009 106(49):20699–20704. doi:10.1073/pnas.0911512106
The tyrosine kinase Csk dimerizes through its SH3 domain
Nicholas M. Levinson, Patrick R. Visperas and John Kuriyan
PLoS One 2009 Nov 4;4(11):e7683. doi: 10.1371/journal.pone.0007683
Mechanism for Activation of the EGF Receptor Catalytic Domain by the Juxtamembrane Segment
Natalia Jura, Nicholas F. Endres, Kate Engel, Sebastian Deindl, Rahul Das, Meindert H. Lamers, David E. Wemmer, Xuewu Zhang and John Kuriyan
Cell 2009 Jun 26;137(7):1293-307. doi: 10.1016/j.cell.2009.04.025
The Mechanism of ATP-Dependent Primer-Template Recognition by a Clamp Loader Complex
Kyle R. Simonetta, Steven L. Kazmirski, Eric R. Goedken, Aaron J. Cantor, Brian A. Kelch, Randall McNally, Steven N. Seyedin, Debora L. Makino, Mike O'Donnell and John Kuriyan
Cell 2009 May 15;137(4):659-71. doi: 10.1016/j.cell.2009.03.044
Equally Potent Inhibition of c-Src and Abl by Compounds that Recognize Inactive Kinase Conformations
Markus A. Seeliger, Pratistha Ranjitkar, Corynn Kasap, Yibing Shan, David E. Shaw, Neil P. Shah, John Kuriyan and Dustin J. Maly
Cancer Res. 2009 Mar 15;69(6):2384-92. doi: 10.1158/0008-5472.CAN-08-3953
The structure of the leukemia drug imatinib bound to human quinone reductase 2 (NQO2)
Jonathan A. Winger, Oliver Hantschel, Giulio Superti-Furga and John Kuriyan
BMC Struct Biol. 2009 Feb 24;9:7. doi: 10.1186/1472-6807-9-7
Differences in Flexibility Underlie Functional Differences in the Ras Activators Son of Sevenless and Ras Guanine Nucleotide Releasing Factor 1
Tanya S. Freedman, Holger Sondermann, Olga Kuchment, Gregory D. Friedland, Tanja Kortemme and John Kuriyan
Structure 2009 Jan 14;17(1):41-53. doi: 10.1016/j.str.2008.11.004
2008
The crystal structure of the catalytic domain of a eukaryotic guanylate cyclase
Jonathan A. Winger, Emily R. Derbyshire, Meindert H. Lamers, Michael A. Marletta and John Kuriyan
BMC Struct Biol. 2008 Oct 7;8:42. doi: 10.1186/1472-6807-8-42
Membrane-dependent signal integration by the Ras activator Son of sevenless
Jodi Gureasko, William J. Galush, Sean Boykevisch, Holger Sondermann, Dafna Bar-Sagi, Jay T. Groves and John Kuriyan
Nat Struct Mol Biol. 2008 May;15(5):452-61. doi: 10.1038/nsmb.1418
Structural Basis for the Recognition of c-Src by Its Inactivator Csk
Nicholas M. Levinson, Markus A. Seeliger, Philip A. Cole and John Kuriyan
Cell 2008 Jul 11;134(1):124-34. doi: 10.1016/j.cell.2008.05.051
2007
Inhibition of the EGF receptor by binding of MIG6 to an activating kinase domain interface
Xuewu Zhang, Kerry A. Pickin, Ron Bose, Natalia Jura, Philip A. Cole, and John Kuriyan
Nature 2007 Nov 29;450(7170):741-4
Structural Basis for the Inhibition of Tyrosine Kinase Activity of ZAP-70
Sebastian Deindl, Theresa A. Kadlecek, Tomas Brdicka, Xiaoxian Cao, Arthur Weiss and John Kuriyan
Cell 2007 May 18;129(4):735-46
c-Src Binds to the Cancer Drug Imatinib with an Inactive Abl/c-Kit Conformation and a Distributed Thermodynamic Penalty
Markus A. Seeliger, Bhushan Nagar, Filipp Frank, Xiaoxian Cao, M. Nidanie Henderson and John Kuriyan
Structure 2007 Mar;15(3):299-311
2006
Protein-protein Interactions in the Allosteric Regulation of Protein Kinases
Patricia Pellicena and John Kuriyan
Curr Opin Struct Biol. 2006 Dec;16(6):702-9
A Ras-induced Conformational Switch in the Ras Activator Son of Sevenless
Tanya S. Freedman*, Holger Sondermann*, Gregory D. Friedland, Tanja Kortemme, Dafna Bar-Sagi, Susan Marqusee and John Kuriyan
Proc Natl Acad Sci U S A 2006 Nov 7;103(45):16692-7
Crystal Structure of the Catalytic α Subunit of E. coli Replicative DNA Polymerase III
Meindert H. Lamers, Roxana E. Georgescu, Sang-Gyu Lee, Mike O'Donnell and John Kuriyan
Cell 2006 Sep 8;126(5):881-92
A Dimeric Kinase Assembly Underlying Autophosphorylation in the p21 Activated Kinases
Michelle Pirruccello, Holger Sondermann, Jeffrey G. Pelton, Patricia Pellicena, André Hoelz, Jonathan Chernoff, David E. Wemmer and John Kuriyan
J Mol Biol. 2006 Aug 11;361(2):312-26
An Allosteric Mechanism for Activation of the Kinase Domain of Epidermal Growth Factor Receptor
Xuewu Zhang, Jodi Gureasko, Kui Shen, Philip A. Cole and John Kuriyan
Cell 2006 Jun 16;125(6):1137-49
A Src-Like Inactive Conformation in the Abl Tyrosine Kinase Domain
Nicholas M. Levinson*, Olga Kuchment*, Kui Shen, Matthew A. Young, Michael Koldobskiy, Martin Karplus, Philip A. Cole and John Kuriyan
PLoS Biol. 2006 May;4(5):e144
Structure of the Kinase Domain of an Imatinib-Resistant Abl Mutant in Complex with the Aurora Kinase Inhibitor VX-680
Matthew A. Young, Neil P. Shah, Luke H. Chao, Markus Seeliger, Zdravko V. Milanov, William H. Biggs, III, Daniel K. Treiber, Hitesh K. Patel, Patrick P. Zarrinkar, David J. Lockhart, Charles L. Sawyers and John Kuriyan
Cancer Res 2006 66(2): 1007-14. doi: 10.1158/0008-5472.CAN-05-2788
Organization of the SH3-SH2 Unit in Active and Inactive Forms of the c-Abl Tyrosine Kinase
Bhushan Nagar, Oliver Hantschel, Markus Seeliger, Jason M. Davies, William I. Weis, Giulio Superti-Furga and John Kuriyan
Mol Cell. 2006 Mar 17;21(6):787-98
Oligomerization states of the association domain and the holoenyzme of Ca2+/CaM kinase II
Oren S. Rosenberg, Sebastian Deindl, Luis R. Comolli, André Hoelz, Kenneth H. Downing, Angus C. Nairn and John Kuriyan
FEBSJ 2006 Vol. 273: 682-694. doi: 10.1111/j.1742-4658.2005.05088.x
Crystal structure of a DNA polymerase sliding clamp from a Gram-positive bacterium
Maria A. Argiriadi, Eric R. Goedken, Irina Bruck, Mike O’Donnell and John Kuriyan
BMC Struct Biol. 2006 Jan 10;6:2
2005
Structure of the Autoinhibited Kinase Domain of CaMKII and SAXS Analysis of the Holoenzyme
Oren S. Rosenberg, Sebastian Deindl, Rou-Jia Sung, Angus C. Nairn and John Kuriyan
Cell 2005 Dec 2;123(5):849-60
High yield bacterial expression of active c-Abl and c-Src tyrosine kinases
Markus A. Seeliger, Matthew Young, M. Nidanie Henderson, Patricia Pellicena, David S. King, Arnold M. Falick and John Kuriyan
Protein Sci. 2005 Dec;14(12):3135-9
Computational Docking and Solution X-ray Scattering Predict a Membrane-interacting Role for the Histone Domain of the Ras-activator Son of Sevenless
Holger Sondermann, Bhushan Nagar, Dafna Bar-Sagi and John Kuriyan
Proc Natl Acad Sci U S A 2005 Nov 15;102(46):16632-7
Out-of-plane motions in open sliding clamps: Molecular dynamics simulations of eukaryotic and archaeal proliferating cell nuclear antigen
Steven L. Kazmirski, Yanxiang Zhao, Gregory D. Bowman, Mike O’Donnell and John Kuriyan
Protein Sci. 2005 Dec;14(12):3135-9
Mapping the interaction of DNA with the Escherichia coli DNA polymerase clamp loader complex
Eric R Goedken, Steven L Kazmirski, Gregory D Bowman, Mike O'Donnell and John Kuriyan
Nat Struct Mol Biol 2005 Feb;12(2):183-90
2004
Structural analysis of the inactive state of the Escherichia coli DNA polymerase clamp-loader complex
Steven L. Kazmirski*, Marjetka Podobnik*, Tanya F. Weitze, Mike O’Donnell and John Kuriyan
Proc Natl Acad Sci U S A 2004 Nov 30;101(48):16750-5
Structural Analysis of Autoinhibition in the Ras Activator Son of Sevenless
Holger Sondermann*, Stephen M. Soisson*, Sean Boykevisch, Shao-Song Yang, Dafna Bar-Sagi and John Kuriyan
Cell 2004 Oct 29;119(3):393-405
Crystal structure of an oxygen-binding heme domain related to soluble guanylate cyclases
Patricia Pellicena, David S. Karow, Elizabeth M. Boon, Michael A. Marletta and John Kuriyan
Proc Natl Acad Sci U S A. 2004 Aug 31;101(35):12854-9
Structural analysis of a eukaryotic sliding DNA clamp-clamp loader complex
Gregory D. Bowman, Mike O'Donnell and John Kuriyan
Nature 2004 Jun 17;429(6993):724-30
Fluorescence Measurements on the E. coli DNA Polymerase Clamp Loader: Implications for Conformational Changes During ATP and Clamp Binding
Eric R. Goedken, Marcia Levitus, Aaron Johnson, Carlos Bustamante, Mike O’Donnell and John Kuriyan
J Mol Biol. 2004 Mar 5;336(5):1047-59
Crystal structure of the chi:psi subassembly of the Escherichia coli DNA polymerase clamp-loader complex
Jacqueline M. Gulbis, Steven L. Kazmirski, Jeff Finkelstein, Zvi Kelman, Mike O'Donnell and John Kuriyan
Eur J Biochem. 2004 Jan;271(2):439-49
2003
Tandem Histone Folds in the Structure of the N-terminal Segment of the Ras Activator Son of Sevenless
Holger Sondermann, Stephen M. Soisson, Dafna Bar-Sagi, and John Kuriyan
Structure 2003 Dec;11(12):1583-93
Crystal Structure of a Tetradecameric Assembly of the Association Domain of Ca2+/Calmodulin-Dependent Kinase II
Andre Hoelz, Angus C. Nairn and John Kuriyan
Mol Cell. 2003 May;11(5):1241-51
Structural evidence for feedback activation by Ras.GTP of the Ras-specific nucleotide exchange factor SOS
S. Mariana Margarit, Holger Sondermann, Brian E. Hall, Bhushan Nagar, Andre Hoelz, Michelle Pirruccello, Dafna Bar-Sagi, and John Kuriyan
Cell 2003 Mar 7;112(5):685-95
Nucleotide-Induced Conformational Changes in an Isolated Escherichia coli DNA Polymerase III Clamp Loader Subunit
Marjetka Podobnik, Tanya F. Weitze, Mike O’Donnell and John Kuriyan
Structure 2003 Mar;11(3):253-63
Structural Basis for the Autoinhibition of c-Abl Tyrosine Kinase
Nagar B, Hantschel O, Young MA, Scheffzek K, Veach D, Bornmann W, Clarkson B, Superti-Furga G, Kuriyan J
Cell 2003 Mar 21;112(6):859-71
A Myristoyl/Phosphotyrosine Switch Regulates c-Abl
Hantschel O, Nagar B, Guettler S, Kretzschmar J, Dorey K, Kuriyan J, Superti-Furga G
Cell 2003 Mar 21;112(6):845-57
Structural Basis for the Autoinhibition of c-Abl Tyrosine Kinase
Xiaomin Chen, Rashna Bhandari, Uwe Vinkemeier, Focco van den Akker, James E. Darnell Jr. and John Kuriyan
Protein Sci. 2003 Feb;12(2):361-5
2002
Crystal Structures of the Kinase Domain of c-Abl in Complex with the Small Molecule Inhibitors PD173955 and STI571
Bhushan Nagar, William Bornmann, Patricia Pellicena, Thomas Schindler, Darren Veach, W. Todd Miller, Bayard Clarkson and John Kuriyan
Cancer Res. 2002 Aug 1;62(15):4236-43
2001
The TGF Receptor Activation Process: An Inhibitor- to Substrate-Binding Switch
Morgan Huse, Tom W. Muir, Lan Xu, Ye-Guang Chen, John Kuriyan and Joan Massagué
Mol Cell. 2001 Sep;8(3):671-82
Mechanism of Processivity Clamp Opening by the Delta Subunit Wrench of the Clamp Loader Complex of E. coli DNA Polymerase III
David Jeruzalmi, Olga Yurieva, Yanxiang Zhao, Matthew Young, Jelena Stewart, Manju Hingorani, Mike O'Donnell and John Kuriyan
Cell 2001 Aug 24;106(4):417-28
Crystal Structure of the Processivity Clamp Loader Gamma Complex of E. coli DNA Polymerase III
David Jeruzalmi, Mike O'Donnell and John Kuriyan
Cell 2001 Aug 24;106(4):429-441
Crystal Structure of the Atypical Protein Kinase Domain of a TRP Channel with Phosphotransferase Activity
Hiroto Yamaguchi, Masayuki Matsushita, Angus C. Nairn and John Kuriyan
Mol Cell 2001 May;7(5):1047-57
Dynamic Coupling Between the SH2 and SH3 Domains of C-Src and Hck Underlies Their Inactivation by C-Terminal Tyrosine Phosphorylation
Matthew A. Young, Stefania Gonfloni, Giulio Superti-Furga, Benoit Roux and John Kuriyan
Cell 2001 Apr 6;105(1):115-26
2000
Structural Mechanism for STI-571 Inhibition of Abelson Tyrosine Kinase
Thomas Schindler, William Bornmann, Patricia Pellicena, W. Todd Miller, Bayard Clarkson and John Kuriyan
Science 2000 Sep 15;289(5486):1938-42
A TOPRIM domain in the crystal structure of the catalytic core of Escherichia coli primase confirms a structural link to DNA topoisomerases
Marjetka Podobnik, Peter McInerney , Mike O'Donnell and John Kuriyan
J Mol Biol. 2000 Jul 7;300(2):353-62
1999
Crystal structure of an archaebacterial DNA polymerase
Yanxiang Zhao, David Jeruzalmi, Ismail Moarefi, Lore Leighton, Roger Lasken and John Kuriyan
Structure 1999 Oct 15;7(10):1189-99
Crystal Structure of Hck in Complex with a Src Family-Selective Tyrosine Kinase Inhibitor
Thomas Schindler, Frank Sicheri, Alexander Pico, Aviv Gazit, Alexander Levitzki and John Kuriyan
Mol Cell. 1999 May;3(5):639-48
Crystal Structure of the Cytoplasmic Domain of the Type I TGFß Receptor in Complex with FKBP12
Morgan Huse, Ye-Guang Chen, Joan Massagué and John Kuriyan
Cell 1999 Feb 5;96(3):425-36
1998
Crystallographic Analysis of the Recognition of a Nuclear Localization Signal by the Nuclear Import Factor Karyopherin alpha
Elena Conti, Marc Uy, Lore Leighton, Günter Blobel and John Kuriyan
Cell 1998 Jul 24;94(2):193-204
Structure of Ras complexed with the Ras exchange factor region of the Son of Sevenless protein
Boriack-Sjodin, P. A., Margarit, S. M., Bar-Sagi, D., and Kuriyan, J.
Nature 1998 Jul 23;394(6691):337-43
Crystal Structure of the Dbl and Pleckstrin Homology Domains from the Human Son of Sevenless Protein
Soisson, S. M., Nimnual, A. S., Uy, M., Bar-Sagi, D., and Kuriyan, J.
Cell 1998 Oct 16;95(2):259-68
Crystal Structure of a Tyrosine Phosphorylated STAT-1 Dimer Bound to DNA
Xiaomin Chen, Uwe Vinkemeier, Yanxiang Zhao, David Jeruzalmi, James E. Darnell, Jr. and John Kuriyan
Cell 1998 May 29;93(5):827-39
1997
Crystal structure of the delta' subunit of the clamp-loader complex of E. coli DNA polymerase III
Guenther, B. D., Onrust, R., Sali, A., O'Donnell, M. and Kuriyan, J.
Cell 1997 Oct 31;91(3):335-45
Crystal Structure of the Src-family tyrosine kinase Hck
Sicheri, F., Moarefi, I. and Kuriyan, J.
Nature 1997 Feb 13;385(6617):602-9
Activation of the Src family tyrosine kinase Hck by SH3 domain displacement
Moarefi, I., LaFevre-Bernt, M., Sicheri, F., Huse, M., Lee, C.-H., Kuriyan, J. and Miller, W.T.
Nature 1997 Feb 13;385(6617):650-3
1996
Structure of the C-terminal region of p21WAF1/CIP1 complexed with human PCNA
Gulbis, J., Kelman, Z., Gibbs, E., Hurwitz, J., O'Donnell, M. and Kuriyan, J.
Cell 1996 Oct 18;87(2):297-306
Crystal structure of the conserved core of HIV-1 Nef complexed with a Src family SH3 domain
Lee, C. H., Saksela, K., Mirza, U. A., Chait, B. T., and Kuriyan, J.
Cell 1996 Jun 14;85(6):931-42
Structural basis for the autoinhibition of calcium/calmodulin-dependent protein kinase I
J. Goldberg, A. Nairn and J. Kuriyan
Cell 1996 Mar 22;84(6):875-87
1995
Three-dimensional structure of the catalytic subunit of protein serine/threonine phosphatase-1
Goldberg, J., H.-b. Huang, Y.-g. Kwon, P. Greengard, A.C. Nairn, and J. Kuriyan
Nature 1995 Aug 31;376(6543):745-53
1994
Crystal structure of the eukaryotic DNA polymerase processivity factor PCNA
Krishna TS, Kong XP, Gary S, Burgers PM and Kuriyan J.
Cell 1994 Dec 30;79(7):1233-43
1992
Crystal structure of the phosphotyrosine recognition domain SH2 of v-src complexed with tyrosine-phosphorylated peptides
G. Waksman, D. Kominos, S.R. Robertson, N. Pant, D. Baltimore, R.B. Birge, D. Cowburn, H. Hanafusa, B.J. Mayer, M. Overduin, M.D. Resh, C.B. Rios, L. Silverman and J. Kuriya.
Nature 1992 Aug 20;358(6388):646-53
Three-dimensional structure of the beta subunit of E. coli DNA Polymerase III Holoenzyme: a sliding DNA clamp
X.-P. Kong, R. Onrust, M.J. O'Donnell and J. Kuriyan
Cell 1992 May 1;69(3):425-37