Kuriyan Lab - Publications

A saturation-mutagenesis analysis of the interplay between stability and activation in Ras

Frank Hidalgo, Laura M. Nocka, Neel H. Shah, Kent Gorday, Naomi R. Latorraca, Pradeep Bandaru, Sage Templeton, David Lee, Deepti Karandur, Jeffery G. Pelton, Susan Marqusee, David E. Wemmer and John Kuriyan

eLife 2022;11:e76595
doi: 10.7554/eLife.76595

2021

A molecular mechanism for the generation of ligand-dependent differential outputs by the epidermal growth factor receptor

Yongjian Huang, Jana Ognjenović, Deepti Karandur, Kate Miller, Alan Merk, Sriram Subramaniam and John Kuriyan

eLife 2021 10:e73218 doi:10.7554/eLife.73218

BioRχiv 2020.12.08.417006; doi: https://doi.org/10.1101/2020.12.08.417006

Differences in the dynamics of the tandem-SH2 modules of the Syk and ZAP-70 tyrosine kinases

Helen T Hobbs, Neel H Shah, Jean M Badroos, Christine L Gee, Susan Marqusee and John Kuriyan

Protein Science 2021 Oct 3. Epub ahead of print. doi:10.1002/pro.4199

BioRχiv 2021.07.20.453126;
doi:https://doi.org/10.1101/2021.07.20.453126

Allosteric communication in DNA polymerase clamp loaders relies on a critical hydrogen-bonded junction

Subu Subramanian, Kent Gorday, Kendra Marcus, Matthew R. Orellana, Peter Ren, Xiao Ran Luo, Mike O’Donnell and John Kuriyan

eLife 2021;10:e66181 doi:10.7554/eLife.66181

BioRχiv 2020.12.31.424921;
doi:https://doi.org/10.1101/2020.12.31.424921

2020

Breakage of the oligomeric CaMKII hub by the regulatory segment of the kinase

Deepti Karandur*, Moitrayee Bhattacharyya*, Zijie Xia*, Young Kwang Lee, Serena Muratcioğlu, Darren McAffee, Ethan D McSpadden, Baiyu Qiu, Jay T Groves, Evan R Williams and John Kuriyan

eLife 2020;9:e57784 doi: 10.7554/eLife.57784
BioRχiv 2020.04.15.043067; doi: https://doi.org/10.1101/2020.04.15.043067

CRISPR-Cas12a exploits R-loop asymmetry to form double-strand breaks

Joshua C Cofsky, Deepti Karandur, Carolyn J Huang, Isaac P Witte, John Kuriyan and Jennifer A Doudna

eLife 2020;9:e55143 doi: 10.7554/eLife.55143

Flexible linkers in CaMKII control the balance between activating and inhibitory autophosphorylation

Moitrayee Bhattacharyya, Young Kwang Lee, Serena Muratcioğlu, Baiyu Qiu, Priya Nyayapati, Howard Schulman, Jay T. Groves and John Kuriyan

eLife 2020;9:e53670 doi:10.7554/eLife.53670

2019

Cryo-EM structure of a dimeric B-Raf:14-3-3 complex reveals asymmetry in the active sites of B-Raf kinases

Yasushi Kondo*, Jana Ognjenović*, Saikat Banerjee, Deepti Karandur, Alan Merk, Kayla Kulhanek, Kathryn Wong, Jeroen P. Roose, Sriram Subramaniam and John Kuriyan

Science 2019 366:109–115 Epub Sep 19
doi: 10.1126/science.aay0543

Switch-like activation of Bruton's tyrosine kinase by membrane-mediated dimerization

Jean K. Chung*, Laura M. Nocka*, Aubrianna Decker, Qi Wang, Theresa A. Kadlecek, Arthur Weiss, John Kuriyan and Jay T. Groves

Proc Natl Acad Sci USA 2019 116(22):10798-10803
doi: https://doi.org/10.1101/284000

BioRχiv 284000; doi: https://doi.org/10.1101/284000

Variation in assembly stoichiometry in non-metazoan homologs of the hub domain of Ca²⁺/Calmodulin-dependent protein kinase II

Ethan D. McSpadden, Zijie Xia, Chris C. Chi, Anna C. Susa, Neel H. Shah, Christine L. Gee, Evan R. Williams and John Kuriyan

Protein Science 2019 28:1071–1082 Epub Apr 3 doi: https://doi.org/10.1002/pro.3614

BioRχiv 536094; doi: https://doi.org/10.1101/536094

Deep mutational analysis reveals functional trade-offs in the sequences of EGFR autophosphorylation sites

Aaron C. Cantor, Neel H. Shah and John Kuriyan

Proc Natl Acad Sci USA 2018 115(31):E7303-E7312 Epub July 16
doi: 10.1073/pnas.18035981152018

BioRχiv 273516; doi: https://doi.org/10.1101/273516

Fine-tuning of substrate preferences of the Src-family kinase Lck revealed through a high-throughput specificity screen

Neel H. Shah, Mark Löbel, Arthur Weiss and John Kuriyan

eLife 2018;7:e35190 doi:10.7554/eLife.35190

BioRχiv 250753; doi: https://doi.org/10.1101/250753

Phosphorylation Control of the Ubiquitin Ligase Cbl is Conserved in Choanoflagellates

Jeanine F. Amacher, Helen T. Hobbs, Aaron C. Cantor, Lochan Shah, Marco-Jose Rivero,
Sarah A. Mulchand and John Kuriyan

Protein Science 2018 27(5):923-932. Epub 2018 Mar 2. doi: 10.1002/pro.3397

A Histidine pH sensor regulates activation of the Ras-specific guanine nucleotide exchange factor RasGRP1

Yvonne Vercoulen*, Yasushi Kondo*, Jeffrey S. Iwig*, Axel B. Janssen, Katharine A. White, Mojtaba Amini, Diane L. Barber, John Kuriyan and Jeroen P. Roose

eLife 2017;6:e29002. doi: 10.7554/eLife.29002

Multiple interactions between an Arf/GEF complex and charged lipids determine activation kinetics on the membrane

Deepti Karandur*, Agata Nawrotek*, John Kuriyan and Jacqueline Cherfils

Proc Natl Acad Sci U S A 2017 Oct 24;114(43):11416-11421. Epub 2017 Sep 18.
doi: 10.1073/pnas.1707970114

Deconstruction of the Ras switching cycle through saturation mutagenesis

Pradeep Bandaru, Neel H. Shah, Moitrayee Bhattacharyya, John P. Barton, Yasushi Kondo, Joshua C. Cofsky, Christine L. Gee, Arup K. Chakraborty, Tanja Kortemme, Rama Ranganathan and John Kuriyan

eLife 2017;6:e27810 doi: 10.7554/eLife.27810

Identification of inhibitors of the association of ZAP-70 with the T cell receptor
by high-throughput screen

Patrick R. Visperas, Christopher G. Wilson, Jonathan A. Winger, Qingrong Yan, Kevin Lin, Michelle R. Arkin, Arthur Weiss and John Kuriyan

SLAS Discov. 2017 Mar 1;22(3):324-331. Epub 2016 Dec 13
doi: 10.1177/1087057116681407

An electrostatic selection mechanism controls sequential kinase signaling downstream of the T cell receptor

Neel H. Shah, Qi Wang, Qingrong Yan, Deepti Karandur, Theresa A. Kadlecek, Ian R. Fallahee, William P. Russ, Rama Ranganathan, Arthur Weiss and John Kuriyan

eLife 2016 Oct 4;5:e20105. doi: 10.7554/eLife.20105

Molecular basis for multimerization in the activation of the epidermal growth factor receptor

Yongjian Huang*, Shashank Bharill*, Deepti Karandur, Sean M. Peterson, Morgan Marita, Xiaojun Shi, Megan J. Kaliszewski, Adam W. Smith, Ehud Y. Isacoff and John Kuriyan

eLife 2016 Mar 28;5:e14107.
doi: 10.7554/eLife.14107.

Molecular mechanism of activation-triggered subunit exchange in Ca²⁺/calmodulin-dependent protein kinase II

Moitrayee Bhattacharyya*, Margaret M. Stratton*, Catherine C. Going*, Ethan McSpadden, Yongjian Huang, Anna C. Susa, Anna Elleman, Yumeng Melody Cao, Nishant Pappireddi, Pawel Burkhardt, Christine L. Gee, Tiago Barros, Howard Schulman, Evan R. Williams and John Kuriyan

eLife 2016 Mar 7;5:e13405.
doi: 10.7554/eLife.13405.

Crystal Structure of a Ube2S-Ubiquitin Conjugate

Sonya Lorenz, Moitrayee Bhattacharyya, Christian Feiler, Michael Rape and John Kuriyan

PLoS One 2016 Feb 1;11(2):e0147550. doi: 10.1371/journal.pone.0147550

Crystal structure of the FLT3 kinase domain bound to the inhibitor Quizartinib (AC220)

Julie A. Zorn, Qi Wang, Eric Fujimura, Tiago Barros and John Kuriyan

PLoS One 2015 Apr 2;10(4):e0121177. doi: 10.1371/journal.pone.0121177

Analysis of the role of the C-terminal tail in the regulation of the epidermal growth factor receptor

Erika Kovacs*, Rahul Das*, Qi Wang, Timothy S. Collier, Aaron Cantor, Yongjian Huang, Kathryn Wong, Amar Mirza, Tiago Barros, Patricia Grob, Natalia Jura, Ron Bose and John Kuriyan

Mol Cell Biol. 2015 Sep 1;35(17):3083-102.
doi: 10.1128/MCB.00248-15. Epub 2015 Jun 29.

Crystal structure of an SH2-kinase construct of c-Abl and effect of the SH2 domain on kinase activity

Sonja Lorenz, Patricia Deng, Oliver Hantschel, Giulio Superti-Furga and John Kuriyan

Biochem. J. 2015, Jun 1;468(2):283-91 doi: 10.1042/BJ20141492

Autoinhibition of Bruton's tyrosine kinase (Btk) and activation by soluble inositol hexakisphosphate

Qi Wang, Erik M Vogan, Laura M Nocka, Connor E Rosen, Julie A Zorn, Stephen C Harrison and John Kuriyan

eLife 2015 10.7554/eLife.06074 doi: 10.7554/eLife.06074

Modification by covalent reaction or oxidation of cysteine residues in the Tandem-SH2 Domains of ZAP-70 and Syk Can Block Phosphopeptide Binding

Patrick R. Visperas, Jonathan A. Winger, Timothy M. Horton, Neel H. Shah, Diane J. Aum, Alyssa Tao, Tiago Barros, Qingrong Yan, Christopher G. Wilson, Michelle R. Arkin, Arthur Weiss and John Kuriyan

Biochem J. 2015;465(1):149-61 doi: 10.1042/BJ20140793

Activation-triggered subunit exchange between CaMKII holoenzymes facilitates the spread of kinase activity

Margaret Stratton, Il-Hyung Lee, Moitrayee Bhattacharyya, Sune M Christensen, Luke H Chao, Howard Schulman, Jay T Groves and John Kuriyan

eLife 2014 Jan 1;3:e01610. doi: 10.7554/eLife.01610

Structural analysis of autoinhibition in the Ras-specific exchange factor RasGRP1

Jeffrey S. Iwig, Yvonne Vercoulen, Rahul Das, Tiago Barros, Andre Limnander, Yan Che, Jeffrey G. Pelton, David E. Wemmer, Jeroen P. Roose and John Kuriyan

eLife 2013 Jul 30;2:e00813. doi: 10.7554/eLife.00813

A structural role for the PHP domain in E. coli DNA polymerase III

Tiago Barros*, Joel Guenther*, Brian Kelch, Jordan Anaya, Arjun Prabhakar, Mike O'Donnell, John Kuriyan and Meindert H. Lamers

BMC Struct Biol. 2013 May 14;13:8.
doi: 10.1186/1472-6807-13-8

A highly efficient peptide substrate for EGFR activates the kinase by inducing aggregation

Kate Engel, Tomoaki Sasaki, Qi Wang and John Kuriyan

Biochem J. 2013 Aug 1;453(3):337-44. doi: 10.1042/BJ20130537

Structural Basis for Activation of ZAP-70 by Phosphorylation of the SH2-Kinase Linker

Qingrong Yan, Tiago Barros, Patrick R. Visperas, Sebastian Deindl, Theresa A. Kadlecek, Arthur Weiss and John Kuriyan

Mol Cell Biol. 2013 Jun;33(11):2188-201. doi: 10.1128/MCB.01637-12

Conformational Coupling across the Plasma Membrane in Activation of the EGF Receptor

Nicholas F. Endres*, Rahul Das*, Adam W. Smith*, Anton Arkhipov, Erika Kovacs, Yongjian Huang, Jeffrey G. Pelton, Yibing Shan, David E. Shaw, David E. Wemmer, Jay T. Groves and John Kuriyan

Cell 2013 Jan 31;152(3):543-56.
doi: 10.1016/j.cell.2012

How a DNA polymerase clamp loader opens a sliding clamp

Brian A. Kelch*, Debora L. Makino*, Michael O'Donnell and John Kuriyan

Science 2011 Dec 23;334(6063):1675-80.
doi: 10.1126/science.1211884

A mechanism for tunable autoinhibition in the structure of a human Ca2+/calmodulin-dependent kinase II holoenzyme

Luke H. Chao, Margaret M. Stratton, Il-Hyung Lee, Oren S. Rosenberg, Joshua Levitz, Daniel J. Mandell, Tanja Kortemme, Jay T. Groves, Howard Schulman and John Kuriyan

Cell 2011 Sep 2;146(5):732-45. doi: 10.1016/j.cell.2011.07.038

The Mechanism of Linkage-Specific Ubiquitin Chain Elongation by a Single-Subunit E2

Katherine E Wickliffe*, Sonja Lorenz*, David E. Wemmer, John Kuriyan and Michael Rape

Cell 2011 Mar 4;144(5):769-81. doi: 10.1016/j.cell.2011.01.035

Intersubunit capture of regulatory segments is a component of cooperative CaMKII activation

Luke H Chao, Patricia Pellicena, Sebastian Deindl, Lauren A Barclay, Howard Schulman and John Kuriyan

Nat Struct Mol Biol. 2010 Mar;17(3):264-72. doi: 10.1038/nsmb.1751

Role of the histone domain in the autoinhibition and activation of the Ras activator Son of Sevenless

Jodi Gureasko, Olga Kuchment, Debora Lika Makino, Holger Sondermann, Dafna Bar-Sagi and John Kuriyan

Proc Natl Acad Sci U S A.2010 Feb 23;107(8):3430-5. doi: 10.1073/pnas.0913915107

Analysis of the role of PCNA-DNA contacts during clamp loading

Randall McNally, Gregory D Bowman, Eric R Goedken, Mike O'Donnell and John Kuriyan

BMC Struct. Biol.2010 Jan 30;10:3. doi: 10.1186/1472-6807-10-3

Structural analysis of the catalytically inactive kinase domain of the human EGF receptor 3

Natalia Jura, Yibing Shan, Xiaoxian Cao, David Shaw and John Kuriyan

Proc Natl Acad Sci U S A.2009 Dec 22;106(51):21608-13. doi: 10.1073/pnas.0912101106

Stability of an autoinhibitory interface in the structure of the tyrosine kinase ZAP-70 impacts T cell receptor response

Sebastian Deindl, Theresa A. Kadlecek, Xiaoxian Cao, John Kuriyan and Arthur Weiss

Proc Natl Acad Sci U S A. 2009 106(49):20699–20704. doi:10.1073/pnas.0911512106

The tyrosine kinase Csk dimerizes through its SH3 domain

Nicholas M. Levinson, Patrick R. Visperas and John Kuriyan

PLoS One 2009 Nov 4;4(11):e7683. doi: 10.1371/journal.pone.0007683

Mechanism for Activation of the EGF Receptor Catalytic Domain by the Juxtamembrane Segment

Natalia Jura, Nicholas F. Endres, Kate Engel, Sebastian Deindl, Rahul Das, Meindert H. Lamers, David E. Wemmer, Xuewu Zhang and John Kuriyan

Cell 2009 Jun 26;137(7):1293-307. doi: 10.1016/j.cell.2009.04.025

The Mechanism of ATP-Dependent Primer-Template Recognition by a Clamp Loader Complex

Kyle R. Simonetta, Steven L. Kazmirski, Eric R. Goedken, Aaron J. Cantor, Brian A. Kelch, Randall McNally, Steven N. Seyedin, Debora L. Makino, Mike O'Donnell and John Kuriyan

Cell 2009 May 15;137(4):659-71. doi: 10.1016/j.cell.2009.03.044

Equally Potent Inhibition of c-Src and Abl by Compounds that Recognize Inactive Kinase Conformations

Markus A. Seeliger, Pratistha Ranjitkar, Corynn Kasap, Yibing Shan, David E. Shaw, Neil P. Shah, John Kuriyan and Dustin J. Maly

Cancer Res. 2009 Mar 15;69(6):2384-92. doi: 10.1158/0008-5472.CAN-08-3953

The structure of the leukemia drug imatinib bound to human quinone reductase 2 (NQO2)

Jonathan A. Winger, Oliver Hantschel, Giulio Superti-Furga and John Kuriyan

BMC Struct Biol. 2009 Feb 24;9:7. doi: 10.1186/1472-6807-9-7

Differences in Flexibility Underlie Functional Differences in the Ras Activators Son of Sevenless and Ras Guanine Nucleotide Releasing Factor 1

Tanya S. Freedman, Holger Sondermann, Olga Kuchment, Gregory D. Friedland, Tanja Kortemme and John Kuriyan

Structure 2009 Jan 14;17(1):41-53. doi: 10.1016/j.str.2008.11.004

The crystal structure of the catalytic domain of a eukaryotic guanylate cyclase

Jonathan A. Winger, Emily R. Derbyshire, Meindert H. Lamers, Michael A. Marletta and John Kuriyan

BMC Struct Biol. 2008 Oct 7;8:42. doi: 10.1186/1472-6807-8-42

Membrane-dependent signal integration by the Ras activator Son of sevenless

Jodi Gureasko, William J. Galush, Sean Boykevisch, Holger Sondermann, Dafna Bar-Sagi, Jay T. Groves and John Kuriyan

Nat Struct Mol Biol. 2008 May;15(5):452-61. doi: 10.1038/nsmb.1418

Structural Basis for the Recognition of c-Src by Its Inactivator Csk

Nicholas M. Levinson, Markus A. Seeliger, Philip A. Cole and John Kuriyan

Cell 2008 Jul 11;134(1):124-34. doi: 10.1016/j.cell.2008.05.051

Inhibition of the EGF receptor by binding of MIG6 to an activating kinase domain interface

Xuewu Zhang, Kerry A. Pickin, Ron Bose, Natalia Jura, Philip A. Cole, and John Kuriyan

Nature 2007 Nov 29;450(7170):741-4

Structural Basis for the Inhibition of Tyrosine Kinase Activity of ZAP-70

Sebastian Deindl, Theresa A. Kadlecek, Tomas Brdicka, Xiaoxian Cao, Arthur Weiss and John Kuriyan

Cell 2007 May 18;129(4):735-46

c-Src Binds to the Cancer Drug Imatinib with an Inactive Abl/c-Kit Conformation and a Distributed Thermodynamic Penalty

Markus A. Seeliger, Bhushan Nagar, Filipp Frank, Xiaoxian Cao, M. Nidanie Henderson and John Kuriyan

Structure 2007 Mar;15(3):299-311

Protein-protein Interactions in the Allosteric Regulation of Protein Kinases

Patricia Pellicena and John Kuriyan

Curr Opin Struct Biol. 2006 Dec;16(6):702-9

A Ras-induced Conformational Switch in the Ras Activator Son of Sevenless

Tanya S. Freedman*, Holger Sondermann*, Gregory D. Friedland, Tanja Kortemme, Dafna Bar-Sagi, Susan Marqusee and John Kuriyan

Proc Natl Acad Sci U S A 2006 Nov 7;103(45):16692-7

Crystal Structure of the Catalytic α Subunit of E. coli Replicative DNA Polymerase III

Meindert H. Lamers, Roxana E. Georgescu, Sang-Gyu Lee, Mike O'Donnell and John Kuriyan

Cell 2006 Sep 8;126(5):881-92

A Dimeric Kinase Assembly Underlying Autophosphorylation in the p21 Activated Kinases

Michelle Pirruccello, Holger Sondermann, Jeffrey G. Pelton, Patricia Pellicena, André Hoelz, Jonathan Chernoff, David E. Wemmer and John Kuriyan

J Mol Biol. 2006 Aug 11;361(2):312-26

An Allosteric Mechanism for Activation of the Kinase Domain of Epidermal Growth Factor Receptor

Xuewu Zhang, Jodi Gureasko, Kui Shen, Philip A. Cole and John Kuriyan

Cell 2006 Jun 16;125(6):1137-49

A Src-Like Inactive Conformation in the Abl Tyrosine Kinase Domain

Nicholas M. Levinson*, Olga Kuchment*, Kui Shen, Matthew A. Young, Michael Koldobskiy, Martin Karplus, Philip A. Cole and John Kuriyan

PLoS Biol. 2006 May;4(5):e144

Structure of the Kinase Domain of an Imatinib-Resistant Abl Mutant in Complex with the Aurora Kinase Inhibitor VX-680

Matthew A. Young, Neil P. Shah, Luke H. Chao, Markus Seeliger, Zdravko V. Milanov, William H. Biggs, III, Daniel K. Treiber, Hitesh K. Patel, Patrick P. Zarrinkar, David J. Lockhart, Charles L. Sawyers and John Kuriyan

Cancer Res 2006 66(2): 1007-14. doi: 10.1158/0008-5472.CAN-05-2788

Organization of the SH3-SH2 Unit in Active and Inactive Forms of the c-Abl Tyrosine Kinase

Bhushan Nagar, Oliver Hantschel, Markus Seeliger, Jason M. Davies, William I. Weis, Giulio Superti-Furga and John Kuriyan

Mol Cell. 2006 Mar 17;21(6):787-98

Oligomerization states of the association domain and the holoenyzme of Ca2+/CaM kinase II

Oren S. Rosenberg, Sebastian Deindl, Luis R. Comolli, André Hoelz, Kenneth H. Downing, Angus C. Nairn and John Kuriyan

FEBSJ 2006 Vol. 273: 682-694. doi: 10.1111/j.1742-4658.2005.05088.x

Crystal structure of a DNA polymerase sliding clamp from a Gram-positive bacterium

Maria A. Argiriadi, Eric R. Goedken, Irina Bruck, Mike O’Donnell and John Kuriyan

BMC Struct Biol. 2006 Jan 10;6:2

Structure of the Autoinhibited Kinase Domain of CaMKII and SAXS Analysis of the Holoenzyme

Oren S. Rosenberg, Sebastian Deindl, Rou-Jia Sung, Angus C. Nairn and John Kuriyan

Cell 2005 Dec 2;123(5):849-60

High yield bacterial expression of active c-Abl and c-Src tyrosine kinases

Markus A. Seeliger, Matthew Young, M. Nidanie Henderson, Patricia Pellicena, David S. King, Arnold M. Falick and John Kuriyan

Protein Sci. 2005 Dec;14(12):3135-9

Computational Docking and Solution X-ray Scattering Predict a Membrane-interacting Role for the Histone Domain of the Ras-activator Son of Sevenless

Holger Sondermann, Bhushan Nagar, Dafna Bar-Sagi and John Kuriyan

Proc Natl Acad Sci U S A 2005 Nov 15;102(46):16632-7

Out-of-plane motions in open sliding clamps: Molecular dynamics simulations of eukaryotic and archaeal proliferating cell nuclear antigen

Steven L. Kazmirski, Yanxiang Zhao, Gregory D. Bowman, Mike O’Donnell and John Kuriyan

Protein Sci. 2005 Dec;14(12):3135-9

Mapping the interaction of DNA with the Escherichia coli DNA polymerase clamp loader complex

Eric R Goedken, Steven L Kazmirski, Gregory D Bowman, Mike O'Donnell and John Kuriyan

Nat Struct Mol Biol 2005 Feb;12(2):183-90

Structural analysis of the inactive state of the Escherichia coli DNA polymerase clamp-loader complex

Steven L. Kazmirski*, Marjetka Podobnik*, Tanya F. Weitze, Mike O’Donnell and John Kuriyan

Proc Natl Acad Sci U S A 2004 Nov 30;101(48):16750-5

Structural Analysis of Autoinhibition in the Ras Activator Son of Sevenless

Holger Sondermann*, Stephen M. Soisson*, Sean Boykevisch, Shao-Song Yang, Dafna Bar-Sagi and John Kuriyan

Cell 2004 Oct 29;119(3):393-405

Crystal structure of an oxygen-binding heme domain related to soluble guanylate cyclases

Patricia Pellicena, David S. Karow, Elizabeth M. Boon, Michael A. Marletta and John Kuriyan

Proc Natl Acad Sci U S A. 2004 Aug 31;101(35):12854-9

Structural analysis of a eukaryotic sliding DNA clamp-clamp loader complex

Gregory D. Bowman, Mike O'Donnell and John Kuriyan

Nature 2004 Jun 17;429(6993):724-30

Fluorescence Measurements on the E. coli DNA Polymerase Clamp Loader: Implications for Conformational Changes During ATP and Clamp Binding

Eric R. Goedken, Marcia Levitus, Aaron Johnson, Carlos Bustamante, Mike O’Donnell and John Kuriyan

J Mol Biol. 2004 Mar 5;336(5):1047-59

Crystal structure of the chi:psi subassembly of the Escherichia coli DNA polymerase clamp-loader complex

Jacqueline M. Gulbis, Steven L. Kazmirski, Jeff Finkelstein, Zvi Kelman, Mike O'Donnell and John Kuriyan

Eur J Biochem. 2004 Jan;271(2):439-49

Tandem Histone Folds in the Structure of the N-terminal Segment of the Ras Activator Son of Sevenless

Holger Sondermann, Stephen M. Soisson, Dafna Bar-Sagi, and John Kuriyan

Structure 2003 Dec;11(12):1583-93

Crystal Structure of a Tetradecameric Assembly of the Association Domain of Ca2+/Calmodulin-Dependent Kinase II

Andre Hoelz, Angus C. Nairn and John Kuriyan

Mol Cell. 2003 May;11(5):1241-51

Structural evidence for feedback activation by Ras.GTP of the Ras-specific nucleotide exchange factor SOS

S. Mariana Margarit, Holger Sondermann, Brian E. Hall, Bhushan Nagar, Andre Hoelz, Michelle Pirruccello, Dafna Bar-Sagi, and John Kuriyan

Cell 2003 Mar 7;112(5):685-95

Nucleotide-Induced Conformational Changes in an Isolated Escherichia coli DNA Polymerase III Clamp Loader Subunit

Marjetka Podobnik, Tanya F. Weitze, Mike O’Donnell and John Kuriyan

Structure 2003 Mar;11(3):253-63

Structural Basis for the Autoinhibition of c-Abl Tyrosine Kinase

Nagar B, Hantschel O, Young MA, Scheffzek K, Veach D, Bornmann W, Clarkson B, Superti-Furga G, Kuriyan J

Cell 2003 Mar 21;112(6):859-71

A Myristoyl/Phosphotyrosine Switch Regulates c-Abl

Hantschel O, Nagar B, Guettler S, Kretzschmar J, Dorey K, Kuriyan J, Superti-Furga G

Cell 2003 Mar 21;112(6):845-57

Structural Basis for the Autoinhibition of c-Abl Tyrosine Kinase

Xiaomin Chen, Rashna Bhandari, Uwe Vinkemeier, Focco van den Akker, James E. Darnell Jr. and John Kuriyan

Protein Sci. 2003 Feb;12(2):361-5

Crystal Structures of the Kinase Domain of c-Abl in Complex with the Small Molecule Inhibitors PD173955 and STI571

Bhushan Nagar, William Bornmann, Patricia Pellicena, Thomas Schindler, Darren Veach, W. Todd Miller, Bayard Clarkson and John Kuriyan

Cancer Res. 2002 Aug 1;62(15):4236-43

The TGF Receptor Activation Process: An Inhibitor- to Substrate-Binding Switch

Morgan Huse, Tom W. Muir, Lan Xu, Ye-Guang Chen, John Kuriyan and Joan Massagué

Mol Cell. 2001 Sep;8(3):671-82

Mechanism of Processivity Clamp Opening by the Delta Subunit Wrench of the Clamp Loader Complex of E. coli DNA Polymerase III

David Jeruzalmi, Olga Yurieva, Yanxiang Zhao, Matthew Young, Jelena Stewart, Manju Hingorani, Mike O'Donnell and John Kuriyan

Cell 2001 Aug 24;106(4):417-28

Crystal Structure of the Processivity Clamp Loader Gamma Complex of E. coli DNA Polymerase III

David Jeruzalmi, Mike O'Donnell and John Kuriyan

Cell 2001 Aug 24;106(4):429-441

Crystal Structure of the Atypical Protein Kinase Domain of a TRP Channel with Phosphotransferase Activity

Hiroto Yamaguchi, Masayuki Matsushita, Angus C. Nairn and John Kuriyan

Mol Cell 2001 May;7(5):1047-57

Dynamic Coupling Between the SH2 and SH3 Domains of C-Src and Hck Underlies Their Inactivation by C-Terminal Tyrosine Phosphorylation

Matthew A. Young, Stefania Gonfloni, Giulio Superti-Furga, Benoit Roux and John Kuriyan

Cell 2001 Apr 6;105(1):115-26

Structural Mechanism for STI-571 Inhibition of Abelson Tyrosine Kinase

Thomas Schindler, William Bornmann, Patricia Pellicena, W. Todd Miller, Bayard Clarkson and John Kuriyan

Science 2000 Sep 15;289(5486):1938-42

A TOPRIM domain in the crystal structure of the catalytic core of Escherichia coli primase confirms a structural link to DNA topoisomerases

Marjetka Podobnik, Peter McInerney , Mike O'Donnell and John Kuriyan

J Mol Biol. 2000 Jul 7;300(2):353-62

Crystal structure of an archaebacterial DNA polymerase

Yanxiang Zhao, David Jeruzalmi, Ismail Moarefi, Lore Leighton, Roger Lasken and John Kuriyan

Structure 1999 Oct 15;7(10):1189-99

Crystal Structure of Hck in Complex with a Src Family-Selective Tyrosine Kinase Inhibitor

Thomas Schindler, Frank Sicheri, Alexander Pico, Aviv Gazit, Alexander Levitzki and John Kuriyan

Mol Cell. 1999 May;3(5):639-48

Crystal Structure of the Cytoplasmic Domain of the Type I TGFß Receptor in Complex with FKBP12

Morgan Huse, Ye-Guang Chen, Joan Massagué and John Kuriyan

Cell 1999 Feb 5;96(3):425-36

Crystallographic Analysis of the Recognition of a Nuclear Localization Signal by the Nuclear Import Factor Karyopherin alpha

Elena Conti, Marc Uy, Lore Leighton, Günter Blobel and John Kuriyan

Cell 1998 Jul 24;94(2):193-204

Structure of Ras complexed with the Ras exchange factor region of the Son of Sevenless protein

Boriack-Sjodin, P. A., Margarit, S. M., Bar-Sagi, D., and Kuriyan, J.

Nature 1998 Jul 23;394(6691):337-43

Crystal Structure of the Dbl and Pleckstrin Homology Domains from the Human Son of Sevenless Protein

Soisson, S. M., Nimnual, A. S., Uy, M., Bar-Sagi, D., and Kuriyan, J.

Cell 1998 Oct 16;95(2):259-68

Crystal Structure of a Tyrosine Phosphorylated STAT-1 Dimer Bound to DNA

Xiaomin Chen, Uwe Vinkemeier, Yanxiang Zhao, David Jeruzalmi, James E. Darnell, Jr. and John Kuriyan

Cell 1998 May 29;93(5):827-39

Crystal structure of the delta' subunit of the clamp-loader complex of E. coli DNA polymerase III

Guenther, B. D., Onrust, R., Sali, A., O'Donnell, M. and Kuriyan, J.

Cell 1997 Oct 31;91(3):335-45

Crystal Structure of the Src-family tyrosine kinase Hck

Sicheri, F., Moarefi, I. and Kuriyan, J.

Nature 1997 Feb 13;385(6617):602-9

Activation of the Src family tyrosine kinase Hck by SH3 domain displacement

Moarefi, I., LaFevre-Bernt, M., Sicheri, F., Huse, M., Lee, C.-H., Kuriyan, J. and Miller, W.T.

Nature 1997 Feb 13;385(6617):650-3

Structure of the C-terminal region of p21WAF1/CIP1 complexed with human PCNA

Gulbis, J., Kelman, Z., Gibbs, E., Hurwitz, J., O'Donnell, M. and Kuriyan, J.

Cell 1996 Oct 18;87(2):297-306

Crystal structure of the conserved core of HIV-1 Nef complexed with a Src family SH3 domain

Lee, C. H., Saksela, K., Mirza, U. A., Chait, B. T., and Kuriyan, J.

Cell 1996 Jun 14;85(6):931-42

Structural basis for the autoinhibition of calcium/calmodulin-dependent protein kinase I

J. Goldberg, A. Nairn and J. Kuriyan

Cell 1996 Mar 22;84(6):875-87

Three-dimensional structure of the catalytic subunit of protein serine/threonine phosphatase-1

Goldberg, J., H.-b. Huang, Y.-g. Kwon, P. Greengard, A.C. Nairn, and J. Kuriyan

Nature 1995 Aug 31;376(6543):745-53

Crystal structure of the eukaryotic DNA polymerase processivity factor PCNA

Krishna TS, Kong XP, Gary S, Burgers PM and Kuriyan J.

Cell 1994 Dec 30;79(7):1233-43

Crystal structure of the phosphotyrosine recognition domain SH2 of v-src complexed with tyrosine-phosphorylated peptides

G. Waksman, D. Kominos, S.R. Robertson, N. Pant, D. Baltimore, R.B. Birge, D. Cowburn, H. Hanafusa, B.J. Mayer, M. Overduin, M.D. Resh, C.B. Rios, L. Silverman and J. Kuriya.

Nature 1992 Aug 20;358(6388):646-53

Three-dimensional structure of the beta subunit of E. coli DNA Polymerase III Holoenzyme: a sliding DNA clamp

X.-P. Kong, R. Onrust, M.J. O'Donnell and J. Kuriyan

Cell 1992 May 1;69(3):425-37

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