Research in Progress

Publications from the lab

Search PubMed for "Kuriyan, J"

John Kuriyan's Page at HHMI


Research Publications and Associated Information
2014 2013 2011 2010 2009 2008 2007 2006 2005 2004 2003 2002 2001 2000 1999 1998 1997 1996 1995 1994 1992 Older & Misc.


2014

Activation-triggered subunit exchange between CaMKII holoenzymes facilitates the spread of kinase activity



2013

Structural analysis of autoinhibition in the Ras-specific exchange factor RasGRP1


A structural role for the PHP domain in E. coli DNA polymerase III


A highly efficient peptide substrate for EGFR activates the kinase by inducing aggregation


Structural Basis for Activation of ZAP-70 by Phosphorylation of the SH2-Kinase Linker


Conformational Coupling across the Plasma Membrane in Activation of the EGF Receptor



2011

How a DNA polymerase clamp loader opens a sliding clamp.


A mechanism for tunable autoinhibition in the structure of a human Ca2+/calmodulin-dependent kinase II holoenzyme


The Mechanism of Linkage-Specific Ubiquitin Chain Elongation by a Single-Subunit E2



2010

Intersubunit capture of regulatory segments is a component of cooperative CaMKII activation


Role of the histone domain in the autoinhibition and activation of the Ras activator Son of Sevenless


Analysis of the role of PCNA-DNA contacts during clamp loading



2009

Structural analysis of the catalytically inactive kinase domain of the human EGF receptor 3


Stability of an autoinhibitory interface in the structure of the tyrosine kinase ZAP-70 impacts T cell receptor response


The tyrosine kinase Csk dimerizes through its SH3 domain


Mechanism for Activation of the EGF Receptor Catalytic Domain by the Juxtamembrane Segment


The Mechanism of ATP-Dependent Primer-Template Recognition by a Clamp Loader Complex


Equally Potent Inhibition of c-Src and Abl by Compounds that Recognize Inactive Kinase Conformations


The structure of the leukemia drug imatinib bound to human quinone reductase 2 (NQO2)


Differences in Flexibility Underlie Functional Differences in the Ras Activators Son of Sevenless and Ras Guanine Nucleotide Releasing Factor 1



2008

The crystal structure of the catalytic domain of a eukaryotic guanylate cyclase


Membrane-dependent signal integration by the Ras activator Son of sevenless


Structural Basis for the Recognition of c-Src by Its Inactivator Csk



2007

Inhibition of the EGF receptor by binding of MIG6 to an activating kinase domain interface


Structural Basis for the Inhibition of Tyrosine Kinase Activity of ZAP-70


c-Src Binds to the Cancer Drug Imatinib with an Inactive Abl/c-Kit Conformation and a Distributed Thermodynamic Penalty



2006

Protein-protein Interactions in the Allosteric Regulation of Protein Kinases


A Ras-induced Conformational Switch in the Ras Activator Son of Sevenless


Crystal Structure of the Catalytic α Subunit of E. coli Replicative DNA Polymerase III


A Dimeric Kinase Assembly Underlying Autophosphorylation in the p21 Activated Kinases


An Allosteric Mechanism for Activation of the Kinase Domain of Epidermal Growth Factor Receptor


A Src-Like Inactive Conformation in the Abl Tyrosine Kinase Domain


Structure of the Kinase Domain of an Imatinib-Resistant Abl Mutant in Complex with the Aurora Kinase Inhibitor VX-680


Organization of the SH3-SH2 Unit in Active and Inactive Forms of the c-Abl Tyrosine Kinase


Oligomerization states of the association domain and the holoenyzme of Ca2+/CaM kinase II


Crystal structure of a DNA polymerase sliding clamp from a Gram-positive bacterium



2005

Structure of the Autoinhibited Kinase Domain of CaMKII and SAXS Analysis of the Holoenzyme


High yield bacterial expression of active c-Abl and c-Src tyrosine kinases


Computational Docking and Solution X-ray Scattering Predict a Membrane-interacting Role for the Histone Domain of the Ras-activator Son of Sevenless


Out-of-plane motions in open sliding clamps: Molecular dynamics simulations of eukaryotic and archaeal proliferating cell nuclear antigen


Mapping the interaction of DNA with the Escherichia coli DNA polymerase clamp loader complex



2004

Structural analysis of the inactive state of the Escherichia coli DNA polymerase clamp-loader complex


Structural Analysis of Autoinhibition in the Ras Activator Son of Sevenless


Crystal structure of an oxygen-binding heme domain related to soluble guanylate cyclases


Structural analysis of a eukaryotic sliding DNA clamp-clamp loader complex.


Fluorescence Measurements on the E. Coli DNA Polymerase Clamp Loader: Implications for Conformational Changes During ATP and Clamp Binding


Crystal structure of the chi:psi subassembly of the Escherichia coli DNA polymerase clamp-loader complex



2003

Tandem Histone Folds in the Structure of the N-terminal Segment of the Ras Activator Son of Sevenless


Crystal Structure of a Tetradecameric Assembly of the Association Domain of Ca2+/Calmodulin-Dependent Kinase II


Structural evidence for feedback activation by Ras·GTP of the Ras-specific nucleotide exchange factor SOS

 

 

 

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Nucleotide-Induced Conformational Changes in an Isolated Escherichia coli DNA Polymerase III Clamp Loader Subunit


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Structural Basis for the Autoinhibition of c-Abl Tyrosine Kinase



A Reinterpretation of the Dimerization Interface of the N-terminal Domains of STATs

 



2002

Crystal Structures of the Kinase Domain of c-Abl
in Complex with the Small Molecule Inhibitors PD173955 and STI571



2001

TGF-beta Receptor Phosphorylation Control


Processivity Clamp Loaders II: The wrench-clamp assembly


Processivity Clamp Loaders II: The clamp loader


Channel kinase


Hck and Src Dynamics



2000

Abl kinase domain

E. coli primase - catalytic core (2000)


1999

D.Tok (1999)

 Hck-PP1 Complex (1999)           

           

Cytoplasmic Domain of Type I TGF-beta Receptor complexed with FKBP12


1998

Karyopherin/Importin-alpha Complex


Ras-Sos Complex       Sos: DH-PH Domains


STATs         


1997

 Polymerase Clamp Loaders

  Src Tyrosine Kinase Hck / (1997)    


1996



Human PCNA Complexed with p21-waf1-cip1



Nef_SH3 Complex

 

     Cam-Kinase-I


1995

PP-1 Phosphatase


1994

Yeast PCNA  


1992

v-Src SH2 Domain; first SH2-peptide complex

beta-subunit of E. coli DNA Polymerase III - A Sliding DNA Clamp


X-11 PTB Domain Complexed with non-phosphorylated peptides:
Zhang, Z., Lee, C.-H., Mandiyan, V., Borg, J.-P., Margolis, B., Schlessinger, J., and Kuriyan, J. (1997).
Sequence-specific recognition of the internalization motif of the Alzheimer's amyloid precursor protein by the X11 PTB domain.
EMBO J., 16, 6141-6150.

1X11 (PDB file)

1AQC (PDB file)


E. Coli GrpE:DnaK Complex:
Harrison, C. J., Hayer-Hartl, M., Di Liberto, M., Hartl, F.-U., and Kuriyan, J. (1997).
Crystal structure of the nucleotide exchange factor GrpE bound to the ATPase domain of the molecular chaperone DnaK.
Science, 276, 431-435.

List of contacts between DnaK and GrpE

Structure of GrpE:DnaK complex (PDB File)








c-Crk SH3 domain, Lys peptide complex

c-Crk SH3 domain, Arg peptide complex

Paired Homeodomain Dimer on DNA


Syp Phosphatase SH2 Domain:
Syp SH2 domain - complex with PDGFR:1009 peptide
Syp SH2 domain - complex with IRS-1:895 peptide
Syp SH2 domain - complex with PDGFR:740 peptide
Syp SH2 domain - uncomplexed form





DsbA : E. coli periplasmic disulfide bond forming protein

Trypanothione reductase from Crithidia fasciculata

Thioredoxin Reductase, E. coli, Wild Type